Adv Exp Med Biol. 2012;741:206-16.
Neural stem cells and transplantation studies in Parkinson’s disease.
Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Sevilla, Spain.
Cell therapy is an emergent alternative therapeutic strategy to PD and consists in the replacement of damaged neurons by new cells that could help to restore the nigrostriatal pathway. For this purpose, stem cells constitute a promising tool that could provide new sources of cells to be used for experimental transplantation studies in PD, as well as in other neurological disorders.
Numerous studies are being made with the use of tissue specific neural progenitors obtained from either fetal or adult nervous systems. In this chapter we will summarize the numerous preclinical and clinical studies performed so far in animal models of the disease as well as in patients and how the use of neural stem cells might improve the current cell therapies.