Early Onset Alzheimer’s Disease Linked to Rapid Cognitive Decline

Most rapid cognitive decline in APOE epsilon4 bad Alzheimer’s illness with early onset

department of Neurology and Alzheimer Centre, VU university scientific Centre, Amsterdam, The Netherlands. ae.vdvlies@vumc.nl
Psychol Med. 2009 Nov;39(eleven):1907-11. Epub  2009 Apr 1.



We aimed to check the rate of cognitive decline in patients with early and late onset Alzheimer’s illness (ad) and to research the doubtless modifying affect of the apolipoprotein E (APOE) genotype.


We integrated ninety nine sufferers with early onset advert (age sixty five years) and 192 sufferers with late onset ad (age >sixty five years) who had at least two rankings on the Mini-mental State Examination (MMSE) (vary 2-14) bought as a minimum 1 12 months apart. Linear mixed models have been performed to research the rate of cognitive decline dependent on age at onset (AAO) and APOE genotype.


The mean (S.D.) age for patients with early onset ad was fifty seven.7 (four.5) years, and seventy four.5 (5.1) years for patients with late onset advert. AAO was no longer associated with baseline MMSE [beta (S.E.)=0.8 (0.5), p=0.14]. on the other hand, patients with early onset confirmed a quicker decline on the MMSE [beta (S.E.)=2.4 (0.1) points/year] than those with late onset [beta (S.E.)=1.7 (0.1) points/year, p=0.00]. After stratification in line with APOE genotype, APOE epsilon4 non-carriers with early onset showed faster cognitive decline than non-carriers with late onset [2.4 (0.3) v. 1.3 (0.3) points/year, p=0.01]. In APOE epsilon4 carriers, no difference in charge of cognitive decline used to be found between patients with early and late onset [beta (S.E.)=0.2 (0.2), p=0.47].


sufferers with early onset ad convey more speedy cognitive decline than patients with late onset, suggesting that early onset ad follows a extra aggressive path. moreover, this effect appears to be most outstanding in sufferers with early onset who do not lift the genetic APOE epsilon4 risk issue for ad.


PMID:19335933[PubMed – listed for MEDLINE