IN THE SPOTLIGHT

How Brain Cells Die in Alzheimer’s and Frontotemporal Dementia

(Emory Health Sciences) Removal of a regulatory gene called LSD1 in adult mice induces changes in gene activity that that look unexpectedly like Alzheimer's disease, scientists have discovered. Researchers also discovered that LSD1 protein is perturbed in brain samples from humans with Alzheimer's disease and frontotemporal dementia (FTD). Based on their findings in human patients and mice, the … [Read More...]

DAILY NEWS

Diet and Alzheimer’s Disease: What the Evidence Shows

(MedScape) Our understanding of dietary influences on Alzheimer's disease is in its infancy, and the number of epidemiologic studies examining promising associations is limited. Thus, at this time, we cannot say with certainty that any particular nutritional component causes or prevents Alzheimer's disease. With that caveat, much of the evidence from early studies in many ways reflects a pattern … [Read More...]

Breaking Down Alzheimer’s: Green Tea Extract Delivers Molecular Punch to Neurotoxic Species

(McMaster University) Green tea is widely considered to be beneficial for the brain. The antioxidant and detoxifying properties of green tea extracts help fight catastrophic diseases such as Alzheimer’s. However, scientists have never fully understood how they work at the molecular level and how they could be harnessed to find better treatments. Research from McMaster University is shedding new … [Read More...]

Growing Human Brain Cells in the Lab

(Gladstone Institutes) Li Gan, PhD, wants to find treatments to help patients with Alzheimer's disease. Like most researchers, she's hit a few major roadblocks. When researchers like Gan find potential new drugs, they must be tested on human cells to confirm they can benefit patients. Historically, these tests have been conducted in cancer cells, which often don't match the biology of human … [Read More...]

New Mechanism Detected in Alzheimer’s Disease

(McGill University) Rate of RNA decay could be a key to breakdown in communication between neurons. McGill University researchers have discovered a cellular mechanism that may contribute to the breakdown of communication between neurons in Alzheimer's disease. Their study, published in Nature Communications, homes in on the role of RNA molecules involved in synaptic transmission -- the … [Read More...]

Young-onset Dementia Costs Nearly Twice That of Alzheimer’s

(Florida Atlantic University) You may not have heard of it, but frontotemporal degeneration (FTD) accounts for 20 to 50 percent of dementia cases in people under the age of 65. FTD ravages an individual's quality of life by dramatically altering their language, personality, behavior, cognition and motor function. But it doesn't end there. Research led by Florida Atlantic University, in … [Read More...]

CAREGIVER’S CORNER

Caregiver Stress Relief Guide: Quick Tips for When You’re Short on Time

(HelpGuide) Sometimes just thinking about embarking on a program of stress control can be stressful. Rather than freeze in your tracks, start small and bask in the glow of your successes. Give yourself a week to focus on practical solutions that could help you cope with just one stumbling block or source of stress in your life. Pick a problem, and … [Read More...]

Why Do People Die from Alzheimer’s Disease?

(AgingCare.com) Dear Readers: I recently went out for coffee with a friend of mine. She wanted to know if people can actually die from Alzheimer's disease. I told her that Alzheimer's is fatal; there is no cure. In late stages of the disease, it affects many functions of the brain and body which will eventually lead to death. Here is a … [Read More...]

Alzheimer’s Disease: Working with Your Family

(UCSF Memory and Aging Center) Family dynamics can change with a serious illness. Being prepared can help family members adjust. As the primary caregiver, friends and family will look to you for information and guidance. Learning about the neurodegenerative disease will help you to answer some of their questions, but you may need a different … [Read More...]

Caregiving at Home: A Guide to Community Resources

(Family Caregiver Alliance) The diagnosis of a dementing illness or disabling health condition marks a new stage in your life and your family’s life. Important decisions about care arise, along with uncertainty and anxiety. Some choices might need to be made right away. Others lie ahead. If you’re caring for someone at home, you may be helping … [Read More...]

Helping Family and Friends Understand Alzheimer’s Disease

(National Institutes of Health) When you learn that someone has Alzheimer’s disease, you may wonder when and how to tell your family and friends. You may be worried about how others will react to or treat the person. Realize that family and friends often sense that something is wrong before they are told. Alzheimer’s disease is hard to keep … [Read More...]

SCIENCE CORNER

Prevention of Alzheimer’s Disease: Lessons Learned and Applied

J Am Geriatr Soc. 2017 Aug 2. doi: 10.1111/jgs.14997. [Epub ahead of print] Prevention of Alzheimer's Disease: Lessons Learned and Applied. Galvin JE1. Abstract Alzheimer's disease (AD) affects more than 5 million Americans, with substantial consequences for individuals with AD, families, and society in terms of morbidity, mortality, and healthcare costs. With disease-modifying treatment trials unsuccessful at the … [Read More...]

Personality Change in the Preclinical Phase of Alzheimer Disease

JAMA Psychiatry. Published online September 20, 2017. doi:10.1001/jamapsychiatry.2017.2816 Personality Change in the Preclinical Phase of Alzheimer Disease Antonio Terracciano, PhD1,2; Yang An, MS2; Angelina R. Sutin, PhD1,2; et al Key Points Question  Do changes in personality traits occur before the onset of mild cognitive impairment or clinical dementia? Findings  In a cohort study that followed up 2046 older adults … [Read More...]

Prevention of Alzheimer’s Disease: Lessons Learned and Applied

J Am Geriatr Soc. 2017 Aug 2. doi: 10.1111/jgs.14997. [Epub ahead of print] Prevention of Alzheimer's Disease: Lessons Learned and Applied. Galvin JE Abstract Alzheimer's disease (AD) affects more than 5 million Americans, with substantial consequences for individuals with AD, families, and society in terms of morbidity, mortality, and healthcare costs. With disease-modifying treatment trials unsuccessful at the … [Read More...]

Dietary and Lifestyle Guidelines for the Prevention of Alzheimer’s Disease

Neurobiol Aging. 2014 Sep;35 Suppl 2:S74-8. doi: 10.1016/j.neurobiolaging.2014.03.033. Epub 2014 May 14. Dietary and lifestyle guidelines for the prevention of Alzheimer's disease. Barnard ND1, Bush AI2, Ceccarelli A3, Cooper J4, de Jager CA5, Erickson KI6, Fraser G7, Kesler S8, Levin SM9, Lucey B10, Morris MC11, Squitti R12. Abstract Risk of developing Alzheimer's disease is increased by older age, genetic factors, … [Read More...]